GTF2IP4

Across TCGA pan-cancer cohorts, GTF2IP4 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GTF2IP4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GTF2IP4 RNA is repressed in tumor relative to normal tissue. In most cancer types GTF2IP4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LIHC, and CHOL are the cancer types where GTF2IP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2IP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.255	<.001	11	view →
LIHC	Female	II,III,IV	+1.342	<.001	8	view →
CHOL	Female	All	+2.913	<.001	3	view →
KIRC	Male	III,IV	−0.463	.009	3	view →
UCEC	All	All	−0.803	.001	2	view →
BLCA	All	All	+0.425	.023	2	view →
COAD	Female	All	−0.584	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

GTF2IP4–KICH

Open the KICH breakdown →