GTF2I

Across TCGA patient cohorts, GTF2I mutation is significantly associated with the RNA expression of many other genes, with 12,548 significant associations in total. THYM shows the largest number of these associations.

The most reproducible GTF2I-associated genes across cancer lineages are NT5C3B, PRKX, and MIR518E. Each is linked with GTF2I in more than 2 cancer types. Because this analysis shows association rather than direction, both GTF2I-to-partner and partner-to-GTF2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NT5C3B grouped by GTF2I-low versus GTF2I-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2I→partner) and Y-score (partner→GTF2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NT5C3B →	+0.698	+2.807	<.001	.003	3	3
THYM	PRKX →	+0.684	+2.799	<.001	<.001	3	3
THYM	MIR518E →	+0.120	+2.309	<.001	.009	3	3
HNSC	PABPC1L2B-AS1 →	+0.027	+5.547	<.001	.001	3	3
CESC	RNU6-147P →	+0.324	+4.812	<.001	.006	3	3
UCEC	TNFSF9 →	+1.759	+3.708	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,548 associations by consensus.

NT5C3B by GTF2I expression — UCEC

Explore this box plot interactively →