GTF2H3

Across TCGA patient cohorts, GTF2H3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2H3-associated genes across cancer lineages are Rad50, EGFR, and ACC_pS79. Each is linked with GTF2H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2H3-to-partner and partner-to-GTF2H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by GTF2H3-low versus GTF2H3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2H3→partner) and Y-score (partner→GTF2H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.255	-2.115	.016	.019	3	2
UCEC	EGFR →	-0.213	-2.973	.002	.035	3	1
UCEC	ACC_pS79 →	+0.396	+3.009	.009	.019	3	1
UCEC	p62 Lck ligand →	+0.415	+3.321	.003	.009	3	1
UCEC	STAT3_pY705 →	-0.385	-2.574	<.001	.010	3	1
UCEC	XBP1 →	-0.144	-2.986	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Rad50 by GTF2H3 expression — UCEC

Explore this box plot interactively →