GTF2H3

Across TCGA pan-cancer cohorts, GTF2H3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GTF2H3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GTF2H3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GTF2H3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where GTF2H3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2H3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.894	<.001	12	view →
LIHC	All	III,IV	+0.930	<.001	9	view →
STAD	All	II,III,IV	+0.891	<.001	9	view →
BLCA	All	III,IV	+0.788	<.001	9	view →
KIRP	All	II,III,IV	+0.704	<.001	9	view →
LUSC	Male	All	+0.874	<.001	6	view →
CHOL	Male	All	+1.658	<.001	5	view →
COAD	Male	All	+0.651	<.001	5	view →
LUAD	Male	All	+0.476	<.001	5	view →
BRCA	All	II,III,IV	+0.277	<.001	4	view →
THCA	All	All	−0.276	.004	4	view →
KIRC	All	All	+0.226	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GTF2H3–HNSC

Open the HNSC breakdown →