GTF2H2

Across TCGA cell cohorts, GTF2H2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,145 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2H2-associated GO terms across cancer lineages are Positive regulation of rRNA processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA 5'-end processing. Each is linked with GTF2H2 in more than 16 cancer types. Because this analysis shows association rather than direction, both GTF2H2-to-partner and partner-to-GTF2H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of rRNA processing grouped by GTF2H2-low versus GTF2H2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2H2→partner) and Y-score (partner→GTF2H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of rRNA processing →	+0.125	+1.016	<.001	<.001	3	17
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.162	+0.898	.002	.002	3	12
LIVER	rRNA 5'-end processing →	+0.162	+0.898	.002	.002	3	12
LARGE_INTESTINE	Protein localization to chromosome →	+0.075	+1.111	<.001	<.001	3	12
URINARY_TRACT	Maturation of SSU-rRNA →	+0.127	+1.321	<.001	.001	3	12
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.134	+1.111	.003	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,145 associations by consensus.

Positive regulation of rRNA processing by GTF2H2 expression — BLOOD_Myeloma

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