GTF2H2

Across TCGA pan-cancer cohorts, GTF2H2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GTF2H2 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher GTF2H2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTF2H2 expression acts as an unfavorable survival marker, although some lineages such as OV and DLBC show a favorable association.

KICH, MESO, and OV are the cancer types where GTF2H2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.289	0.901	.002	25	view →
MESO	DFS	Quartile	II,III,IV	0.199	0.501	.002	21	view →
OV	OS	Quartile	II,III,IV	0.378	0.260	.006	18	view →
KIRP	DFS	Median	IV	0.040	0.622	.006	18	view →
LIHC	OS	Quartile	All	0.690	0.853	.016	16	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	16	view →
LGG	DFS	Quartile	All	0.736	0.908	.001	14	view →
CESC	DFS	Tertile	All	0.765	0.892	.002	12	view →
CHOL	OS	Quartile	II,III,IV	0.316	0.935	.024	12	view →
UCS	OS	Quartile	III,IV	0.241	0.683	.016	12	view →
COAD	OS	Tertile	IV	0.301	0.747	.009	10	view →
ACC	OS	Quartile	IV	0.361	0.844	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GTF2H2–KICH (DFS)

Open the KICH breakdown →