GTF2B

Across TCGA patient cohorts, GTF2B mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2B-associated genes across cancer lineages are CD8+ naive T-cells, Adipocytes, and mv Endothelial cells. Each is linked with GTF2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2B-to-partner and partner-to-GTF2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by GTF2B-low versus GTF2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2B→partner) and Y-score (partner→GTF2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ naive T-cells →	+0.049	+2.949	<.001	<.001	3	1
UCEC	Adipocytes →	+0.020	+1.922	.008	.011	3	1
UCEC	mv Endothelial cells →	-0.027	-3.321	.007	.010	3	1
UCEC	lymphatic Endothelial cells →	-0.023	-2.544	.022	.011	2	1
UCEC	Class-switched memory B-cells →	-0.064	-4.000	.007	<.001	1	1
UCEC	Endothelial cells →	-0.044	-3.957	.006	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD8+ naive T-cells by GTF2B expression — UCEC

Explore this box plot interactively →