GTF2B

Across TCGA pan-cancer cohorts, GTF2B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GTF2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GTF2B RNA is repressed in tumor relative to normal tissue. In most cancer types GTF2B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LIHC, and LUSC are the cancer types where GTF2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.719	<.001	11	view →
LIHC	All	III,IV	+0.695	<.001	9	view →
LUSC	All	II,III,IV	−0.467	<.001	5	view →
CHOL	All	All	+1.048	<.001	3	view →
ESCA	All	All	+0.718	.019	2	view →
STAD	All	II,III,IV	+0.338	.010	2	view →
KIRP	All	All	−0.244	.033	2	view →
LUAD	Female	II,III,IV	−0.234	.023	2	view →
THCA	All	All	−0.214	.002	2	view →
PAAD	Male	All	+0.104	.036	2	view →
KIRC	Female	All	+0.220	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GTF2B–KICH

Open the KICH breakdown →