GTF2B

Across TCGA cell cohorts, GTF2B mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2B-associated genes across cancer lineages are C6orf118, PNMA3, and ASPN. Each is linked with GTF2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2B-to-partner and partner-to-GTF2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by GTF2B-low versus GTF2B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2B→partner) and Y-score (partner→GTF2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.152	+3.115	<.001	.004	3	1
LARGE_INTESTINE	PNMA3 →	+0.162	+2.781	<.001	.009	3	1
LARGE_INTESTINE	ASPN →	+0.048	+3.426	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

C6orf118 by GTF2B expression — LARGE_INTESTINE

Explore this box plot interactively →