GTF2A1L

Across TCGA pan-cancer cohorts, GTF2A1L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GTF2A1L data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GTF2A1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTF2A1L expression acts as an unfavorable survival marker, although some lineages such as LIHC and KIRC show a favorable association.

UCEC, COAD, and LIHC are the cancer types where GTF2A1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.416	0.654	.007	90	view →
COAD	OS	Tertile	II,III,IV	0.255	0.714	.001	55	view →
LIHC	DFS	Tertile	II,III,IV	0.754	0.341	<.001	33	view →
READ	DFS	Quartile	IV	0.179	0.704	<.001	25	view →
KIRC	DFS	Tertile	IV	0.652	0.372	.018	16	view →
THCA	DFS	Tertile	All	0.979	0.910	.005	14	view →
STAD	DFS	Quartile	IV	0.087	0.463	.008	12	view →
HNSC	DFS	Tertile	II,III,IV	0.546	0.708	.011	12	view →
LGG	OS	Quartile	All	0.893	0.744	.014	12	view →
MESO	OS	Quartile	All	0.731	0.258	.040	12	view →
BRCA	OS	Quartile	II,III,IV	0.398	0.618	.007	10	view →
ACC	OS	Tertile	III,IV	0.154	0.511	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GTF2A1L–UCEC (DFS)

Open the UCEC breakdown →