GTF2A1L

Across TCGA pan-cancer cohorts, GTF2A1L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GTF2A1L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GTF2A1L RNA is repressed in tumor relative to normal tissue. In most cancer types GTF2A1L is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where GTF2A1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2A1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.144	<.001	7	view →
KIRP	All	All	−0.047	<.001	7	view →
KIRC	Male	II,III,IV	−0.058	.003	5	view →
BRCA	All	II,III,IV	−0.027	.005	4	view →
BLCA	All	All	−0.192	.045	3	view →
UCEC	All	All	−0.113	.022	2	view →
STAD	All	All	−0.103	.015	2	view →
HNSC	Male	All	+0.063	.036	2	view →
READ	All	All	−0.180	.012	1	view →
LUSC	All	All	+0.054	.014	1	view →
LUAD	All	III,IV	−0.036	.048	1	view →
COAD	Female	All	−0.033	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GTF2A1L–KICH

Open the KICH breakdown →