GTDC1

Across TCGA cell cohorts, GTDC1 mutation is significantly associated with the mutation status of many other genes, with 3,577 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTDC1-associated genes across cancer lineages are KDM5A, SCN8A, and CTNND1. Each is linked with GTDC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GTDC1-to-partner and partner-to-GTDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDM5A grouped by GTDC1-low versus GTDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTDC1→partner) and Y-score (partner→GTDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDM5A →	+1.974	+3.801	.004	.004	1	5
UPPER_AERODIGESTIVE_TRACT	SCN8A →	+4.954	+4.392	.008	.008	1	5
BLOOD_Lymphoma	CTNND1 →	+5.014	+5.584	.003	.003	1	4
OVARY	SH3PXD2A →	+5.415	+5.415	.004	.004	1	4
BLOOD_Lymphoma	RO60 →	+6.014	+6.014	.001	.001	1	4
BLOOD_Lymphoma	DHX37 →	+5.014	+5.584	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,577 associations by consensus.

KDM5A by GTDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →