GSTM5P1

Across TCGA pan-cancer cohorts, GSTM5P1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated GSTM5P1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher GSTM5P1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GSTM5P1 expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

UCS, BLCA, and ACC are the cancer types where GSTM5P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	II,III,IV	0.690	0.171	.004	88	view →
BLCA	DFS	Tertile	II,III,IV	0.530	0.666	.006	49	view →
ACC	DFS	Tertile	All	0.675	0.353	.005	48	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
HNSC	OS	Tertile	IV	0.839	0.668	.004	30	view →
PAAD	OS	Tertile	II,III,IV	0.839	0.380	.005	30	view →
OV	OS	Quartile	IV	0.630	0.232	<.001	30	view →
LAML	DFS	Quartile	All	0.380	0.649	.017	16	view →
THCA	DFS	Tertile	IV	0.568	0.963	.004	12	view →
KICH	DFS	Tertile	II,III,IV	0.102	0.775	.025	9	view →
LIHC	OS	Tertile	III,IV	0.444	0.634	.017	9	view →
ESCA	OS	Tertile	IV	0.713	0.243	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GSTM5P1–UCS (DFS)

Open the UCS breakdown →