GSTM5P1

Across TCGA pan-cancer cohorts, GSTM5P1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GSTM5P1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where GSTM5P1 RNA is repressed in tumor relative to normal tissue. In most cancer types GSTM5P1 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, KIRP, and LUAD are the cancer types where GSTM5P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSTM5P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.126	<.001	6	view →
KIRP	All	All	−0.072	<.001	5	view →
LUAD	Female	All	−0.086	.002	3	view →
KICH	All	All	−0.031	.011	3	view →
HNSC	Female	III,IV	−0.054	.007	2	view →
KIRC	All	All	−0.026	.007	2	view →
ESCA	All	All	−0.210	.008	1	view →
LUSC	All	All	+0.073	.022	1	view →
THCA	Male	All	−0.034	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GSTM5P1–BRCA

Open the BRCA breakdown →