GSTM4

Across TCGA patient cohorts, GSTM4 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSTM4-associated genes across cancer lineages are eIF4E, FoxM1, and Rab25. Each is linked with GSTM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTM4-to-partner and partner-to-GSTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GSTM4-low versus GSTM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM4→partner) and Y-score (partner→GSTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.265	+3.459	.012	.005	3	2
UCEC	FoxM1 →	+0.344	+3.179	.008	.010	3	1
UCEC	Rab25 →	-0.335	-3.000	.044	.036	3	1
UCEC	STAT3_pY705 →	-0.320	-2.999	.015	.035	3	1
UCEC	ATM →	-0.514	-2.986	.024	.035	3	1
UCEC	p90 RSK →	+0.289	+3.009	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by GSTM4 expression — UCEC

Explore this box plot interactively →