GSTM4

Across TCGA pan-cancer cohorts, GSTM4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GSTM4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GSTM4 RNA is repressed in tumor relative to normal tissue. In most cancer types GSTM4 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where GSTM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSTM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.025	<.001	12	view →
KICH	All	III,IV	−1.744	<.001	11	view →
THCA	Male	All	−0.645	<.001	9	view →
LIHC	Female	All	+0.696	<.001	6	view →
UCEC	All	All	−0.761	.003	4	view →
BRCA	All	II,III,IV	−0.341	<.001	4	view →
KIRC	Male	All	−0.338	<.001	4	view →
LUSC	All	All	+0.527	.005	3	view →
KIRP	Male	All	−0.521	<.001	3	view →
PRAD	All	All	−1.149	<.001	2	view →
CHOL	All	All	+0.800	.035	2	view →
READ	All	All	−0.672	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GSTM4–COAD

Open the COAD breakdown →