GSTM4

Across TCGA cell cohorts, GSTM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,112 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GSTM4-associated GO terms across cancer lineages are Xenobiotic catabolic process, Nitrobenzene metabolic process, and Fatty acid catabolic process. Each is linked with GSTM4 in more than 10 cancer types. Because this analysis shows association rather than direction, both GSTM4-to-partner and partner-to-GSTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Xenobiotic catabolic process grouped by GSTM4-low versus GSTM4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM4→partner) and Y-score (partner→GSTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Xenobiotic catabolic process →	+0.208	+1.751	<.001	.001	3	11
BLOOD_Lymphoma	Nitrobenzene metabolic process →	+1.289	+1.535	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Fatty acid catabolic process →	+0.104	+2.236	<.001	<.001	3	10
LIVER	Fatty acid beta-oxidation →	+0.093	+2.491	.006	<.001	3	10
LUNG_NSCLC_LUSC	Glutathione metabolic process →	+0.160	+2.758	.001	<.001	3	10
BLOOD_Lymphoma	Cellular response to caffeine →	+1.054	+1.073	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

Xenobiotic catabolic process by GSTM4 expression — LUNG_SCLC

Explore this box plot interactively →