GSTA5

Across TCGA pan-cancer cohorts, GSTA5 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated GSTA5 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GSTA5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GSTA5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, MESO, and UCEC are the cancer types where GSTA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.634	0.392	<.001	78	view →
MESO	DFS	Tertile	All	0.106	0.369	.016	54	view →
UCEC	DFS	Tertile	IV	0.214	0.639	.001	44	view →
ACC	OS	Quartile	All	0.901	0.493	.001	42	view →
KIRP	DFS	Tertile	All	0.748	0.930	.005	42	view →
LUAD	OS	Quartile	II,III,IV	0.732	0.449	.003	38	view →
LGG	DFS	Tertile	All	0.423	0.848	.002	33	view →
LUSC	OS	Tertile	IV	0.057	0.852	.017	30	view →
PAAD	OS	Tertile	III,IV	0.558	0.924	.014	24	view →
STAD	OS	Quartile	II,III,IV	0.209	0.581	<.001	18	view →
SKCM	DFS	Tertile	III,IV	0.058	0.648	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

GSTA5–KIRC (DFS)

Open the KIRC breakdown →