GSTA3

Across TCGA pan-cancer cohorts, GSTA3 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated GSTA3 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GSTA3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GSTA3 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUAD show a favorable association.

UVM, CHOL, and BLCA are the cancer types where GSTA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.807	0.371	<.001	146	view →
CHOL	OS	Tertile	III,IV	0.024	0.772	.008	36	view →
BLCA	DFS	Tertile	II,III,IV	0.528	0.668	.002	34	view →
READ	OS	Tertile	IV	0.077	1.000	.014	27	view →
LUAD	OS	Quartile	All	0.785	0.629	.007	17	view →
THCA	OS	Tertile	IV	0.790	1.000	.016	12	view →
PAAD	DFS	Tertile	III,IV	0.357	0.908	.038	8	view →
KIRP	OS	Tertile	All	0.863	0.945	.013	6	view →
ACC	DFS	Median	All	0.306	0.610	.008	5	view →
LUSC	DFS	Median	II,III,IV	0.768	0.541	.031	3	view →
KIRC	OS	Median	All	0.772	0.831	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

GSTA3–UVM (DFS)

Open the UVM breakdown →