GSS

Across TCGA patient cohorts, GSS mutation is significantly associated with the RNA expression of many other genes, with 2,288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSS-associated genes across cancer lineages are LINC02277, RALBP1P2, and MRPL32P1. Each is linked with GSS in more than 2 cancer types. Because this analysis shows association rather than direction, both GSS-to-partner and partner-to-GSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02277 grouped by GSS-low versus GSS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSS→partner) and Y-score (partner→GSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02277 →	+0.131	+2.537	<.001	.006	3	3
SKCM	RALBP1P2 →	+0.082	+2.678	<.001	.004	3	3
BLCA	MRPL32P1 →	+0.111	+4.147	<.001	.009	3	2
BLCA	RPS24P14 →	+0.101	+3.577	<.001	.007	3	2
BLCA	TIMM8BP1 →	+0.145	+4.814	<.001	.003	3	2
UCEC	NDUFAF5 →	+0.455	+3.245	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,288 associations by consensus.

LINC02277 by GSS expression — SKCM

Explore this box plot interactively →