Across TCGA patient cohorts, GSPT2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,686 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GSPT2-associated genes across cancer lineages are FAM66B, RNF180, and SLC66A1L. Each is linked with GSPT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both GSPT2-to-partner and partner-to-GSPT2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT2→partner) and Y-score (partner→GSPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM66B →	+0.354	+0.520	.005	.001	3	5
GBM	RNF180 →	+0.991	+0.203	<.001	.002	2	5
LSCC	SLC66A1L →	+0.679	+0.361	.003	.003	3	4
UCEC	GPR173 →	+1.061	+0.619	<.001	<.001	3	4
LSCC	NUDT11 →	+1.001	+0.318	.001	<.001	3	4
UCEC	WNK3 →	+1.014	+0.612	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,686 associations by consensus.

Exploration

GSPT2 survival (RNA) · tumor vs normal (RNA) · all GSPT2 data types