Across TCGA patient cohorts, GSPT2 mutation is significantly associated with the RNA expression of many other genes, with 4,793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSPT2-associated genes across cancer lineages are RN7SL134P, VAC14, and VTRNA2-2P. Each is linked with GSPT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GSPT2-to-partner and partner-to-GSPT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT2→partner) and Y-score (partner→GSPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL134P →	+0.105	+3.289	<.001	.003	3	3
UCEC	VAC14 →	+0.412	+1.656	<.001	<.001	3	3
COAD	VTRNA2-2P →	+0.379	+5.149	<.001	.001	3	2
HNSC	RNA5SP240 →	+0.197	+4.883	<.001	.004	3	2
BLCA	RNU6-650P →	+0.441	+4.623	<.001	.001	3	2
HNSC	LINC02218 →	+0.091	+3.685	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,793 associations by consensus.

Exploration

GSPT2 survival (RNA) · tumor vs normal (RNA) · all GSPT2 data types