Across TCGA patient cohorts, GSPT2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSPT2-associated genes across cancer lineages are Akt_pT308, Bax, and INPP4B. Each is linked with GSPT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GSPT2-to-partner and partner-to-GSPT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT2→partner) and Y-score (partner→GSPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.395	+1.169	.029	.017	3	3
UCEC	Bax →	+0.165	+1.514	.016	.012	3	3
UCEC	INPP4B →	-0.268	-2.321	.003	<.001	3	2
UCEC	Annexin-1 →	+0.604	+2.662	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.346	+2.235	.003	.005	3	2
UCEC	Shc_pY317 →	-0.140	-1.362	.001	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

GSPT2 survival (RNA) · tumor vs normal (RNA) · all GSPT2 data types