GSN

Across TCGA pan-cancer cohorts, GSN Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GSN data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher GSN Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSN expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KICH, UCEC, and ACC are the cancer types where GSN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.043	0.971	<.001	33	view →
UCEC	DFS	Median	III,IV	1.000	0.541	.034	10	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	DFS	Median	II,III,IV	1.000	0.561	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GSN–KICH (DFS)

Open the KICH breakdown →