GSN

Across TCGA pan-cancer cohorts, GSN RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GSN’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GSN RNA is repressed in tumor relative to normal tissue. In most cancer types GSN is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LIHC are the cancer types where GSN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−3.378	<.001	12	view →
COAD	Female	II,III,IV	−1.737	<.001	12	view →
LIHC	Female	All	+1.333	<.001	9	view →
LUAD	Male	All	−0.843	<.001	8	view →
READ	Female	All	−2.600	<.001	7	view →
KIRP	Male	All	−0.973	<.001	7	view →
UCEC	All	All	−2.908	<.001	6	view →
BRCA	All	II,III,IV	−2.452	<.001	6	view →
KICH	Male	All	−0.976	<.001	6	view →
KIRC	Female	All	+0.893	<.001	6	view →
STAD	Female	All	−2.102	<.001	5	view →
CHOL	All	All	+2.124	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GSN–BLCA

Open the BLCA breakdown →