GSN

Across TCGA pan-cancer cohorts, GSN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GSN data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GSN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSN expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where GSN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.274	1.000	.001	48	view →
LSCC	OS	Tertile	All	0.603	1.000	.006	25	view →
CCRCC	OS	Median	II,III,IV	0.454	1.000	.014	8	view →
PDAC	DFS	Tertile	III,IV	0.139	0.566	.019	6	view →
OV	DFS	Median	All	0.907	0.638	.027	4	view →
GBM	DFS	Quartile	All	0.332	0.551	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GSN–UCEC (DFS)

Open the UCEC breakdown →