GSN

Across TCGA patient cohorts, GSN mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSN-associated genes across cancer lineages are p38-MAPK_pT180_Y182, p62 Lck ligand, and EGFR_pY1068. Each is linked with GSN in more than 1 cancer types. Because this analysis shows association rather than direction, both GSN-to-partner and partner-to-GSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by GSN-low versus GSN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSN→partner) and Y-score (partner→GSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.516	-1.501	<.001	.015	3	2
UCEC	p62 Lck ligand →	+0.482	+4.169	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.257	-2.807	.002	.003	3	1
UCEC	eIF4E →	+0.152	+2.013	.034	.016	3	1
UCEC	ERK2 →	+0.181	+2.700	.005	.005	3	1
UCEC	HER2_pY1248 →	-0.181	-2.523	.047	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p38-MAPK_pT180_Y182 by GSN expression — UCEC

Explore this box plot interactively →