GSN

Across TCGA cell cohorts, GSN mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSN-associated genes across cancer lineages are GTSF1L, PDCL2, and SPDYE4. Each is linked with GSN in more than 1 cancer types. Because this analysis shows association rather than direction, both GSN-to-partner and partner-to-GSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTSF1L grouped by GSN-low versus GSN-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSN→partner) and Y-score (partner→GSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GTSF1L →	+0.040	+5.781	<.001	.001	3	1
BLOOD_Lymphoma	PDCL2 →	+0.200	+3.514	<.001	.001	3	1
BLOOD_Lymphoma	SPDYE4 →	+0.136	+3.165	<.001	.004	3	1
BLOOD_Lymphoma	DYTN →	+0.130	+2.874	<.001	.009	3	1
BLOOD_Lymphoma	EXOC1L →	+0.454	+3.781	<.001	<.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GTSF1L by GSN expression — BREAST

Explore this box plot interactively →