GSN-AS1

Across TCGA pan-cancer cohorts, GSN-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GSN-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher GSN-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GSN-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

UVM, HNSC, and LGG are the cancer types where GSN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	III,IV	0.341	0.900	<.001	53	view →
HNSC	DFS	Tertile	II,III,IV	0.710	0.524	.003	52	view →
LGG	DFS	Tertile	All	0.651	0.809	<.001	39	view →
BLCA	DFS	Median	All	0.343	0.614	<.001	35	view →
THCA	OS	Median	III,IV	0.327	1.000	.005	24	view →
OV	OS	Quartile	III,IV	0.751	0.854	.010	20	view →
KIRC	DFS	Median	II,III,IV	0.437	0.593	.006	18	view →
ESCA	OS	Quartile	All	0.865	0.618	.010	15	view →
BRCA	DFS	Tertile	III,IV	0.831	0.713	.017	14	view →
ACC	DFS	Median	II,III,IV	0.662	0.356	.021	13	view →
UCS	DFS	Tertile	IV	0.975	0.459	.024	12	view →
CESC	OS	Quartile	IV	0.783	0.236	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GSN-AS1–UVM (OS)

Open the UVM breakdown →