GSN-AS1

Across TCGA pan-cancer cohorts, GSN-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GSN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GSN-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GSN-AS1 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

HNSC, READ, and COAD are the cancer types where GSN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.128	<.001	10	view →
READ	All	III,IV	−0.195	.003	5	view →
COAD	All	II,III,IV	−0.111	.011	5	view →
CHOL	All	All	+0.245	.002	4	view →
LIHC	Male	II,III,IV	+0.042	.005	4	view →
LUSC	All	All	−0.197	.002	3	view →
BRCA	All	III,IV	−0.292	.001	2	view →
UCEC	All	All	−0.230	.018	2	view →
KIRP	All	All	−0.161	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GSN-AS1–HNSC

Open the HNSC breakdown →