GSEC

Across TCGA pan-cancer cohorts, GSEC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GSEC data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GSEC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSEC expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

LUAD, UVM, and ACC are the cancer types where GSEC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.719	0.860	<.001	123	view →
UVM	DFS	Tertile	III,IV	0.192	0.862	<.001	103	view →
ACC	DFS	Median	All	0.244	0.680	<.001	88	view →
KIRC	DFS	Median	II,III,IV	0.400	0.628	<.001	84	view →
UCS	OS	Median	IV	0.817	0.302	.002	78	view →
KIRP	DFS	Tertile	All	0.534	0.778	<.001	72	view →
LIHC	OS	Tertile	All	0.570	0.768	<.001	65	view →
SKCM	DFS	Quartile	II,III,IV	0.339	0.170	<.001	53	view →
BRCA	OS	Median	III,IV	0.847	0.955	<.001	41	view →
HNSC	OS	Median	All	0.609	0.807	.001	30	view →
THCA	OS	Median	IV	0.541	0.924	.004	24	view →
STAD	OS	Tertile	All	0.479	0.715	.010	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GSEC–LUAD (DFS)

Open the LUAD breakdown →