GSEC

Across TCGA pan-cancer cohorts, GSEC RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GSEC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GSEC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GSEC is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where GSEC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSEC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.321	<.001	12	view →
LIHC	Male	II,III,IV	+1.132	<.001	8	view →
LUAD	Male	II,III,IV	+1.440	<.001	7	view →
COAD	All	II,III,IV	+0.492	<.001	7	view →
BRCA	Female	All	+0.846	<.001	6	view →
LUSC	All	II,III,IV	+0.547	<.001	6	view →
CHOL	Male	All	+1.766	<.001	5	view →
STAD	All	All	+0.438	.001	5	view →
KIRC	Male	All	−0.327	.001	4	view →
KIRP	Female	II,III,IV	+1.333	.042	2	view →
ESCA	Male	All	+0.644	.006	2	view →
READ	All	III,IV	+0.480	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GSEC–HNSC

Open the HNSC breakdown →