GSDMD

Across TCGA patient cohorts, GSDMD RNA expression is significantly associated with the protein abundance of many other proteins, with 7,737 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GSDMD-associated proteins across cancer lineages are PSME1, PSME2, and DTX3L. Each is linked with GSDMD in more than 5 cancer types. Because this analysis shows association rather than direction, both GSDMD-to-partner and partner-to-GSDMD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSDMD versus PSME1 in OV, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMD→partner) and Y-score (partner→GSDMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PSME1 →	+0.389	+0.620	<.001	.001	3	6
OV	PSME2 →	+0.369	+0.645	.006	.001	3	6
GBM	DTX3L →	+0.560	+0.842	<.001	<.001	3	5
LSCC	DDX60 →	+0.465	+0.435	<.001	.001	3	5
GBM	OASL →	+0.651	+0.578	.001	.005	3	5
GBM	IFI35 →	+0.354	+0.563	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,737 associations by consensus.

GSDMD vs PSME1 — OV

Explore this scatter interactively →