GSDMD

Across TCGA pan-cancer cohorts, GSDMD RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GSDMD data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GSDMD RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSDMD expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

UVM, SKCM, and ACC are the cancer types where GSDMD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.421	0.764	<.001	123	view →
SKCM	OS	Tertile	All	0.388	0.276	<.001	64	view →
ACC	DFS	Median	All	0.247	0.623	<.001	57	view →
LGG	DFS	Median	All	0.251	0.493	<.001	53	view →
KIRC	DFS	Median	All	0.755	0.850	.001	38	view →
READ	DFS	Median	All	0.798	0.256	.001	33	view →
LUSC	DFS	Quartile	All	0.288	0.496	.002	22	view →
MESO	OS	Median	III,IV	0.754	0.324	.012	15	view →
LIHC	OS	Quartile	All	0.521	0.756	.005	15	view →
CHOL	OS	Quartile	All	0.792	0.184	.006	13	view →
COAD	DFS	Quartile	All	0.490	0.804	.012	7	view →
SCLC	OS	Median	II,III,IV	0.505	0.760	.010	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GSDMD–UVM (DFS)

Open the UVM breakdown →