GSDMD

Across TCGA patient cohorts, GSDMD protein abundance is significantly associated with the RNA expression of many other genes, with 16,969 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GSDMD-associated genes across cancer lineages are UBE2L6, PARP10, and PSMB9. Each is linked with GSDMD in more than 7 cancer types. Because this analysis shows association rather than direction, both GSDMD-to-partner and partner-to-GSDMD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSDMD versus UBE2L6 in COAD, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMD→partner) and Y-score (partner→GSDMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBE2L6 →	+1.027	+0.326	<.001	<.001	3	8
BRCA	PARP10 →	+1.044	+0.313	<.001	<.001	3	7
BRCA	PSMB9 →	+1.098	+0.362	<.001	<.001	3	7
HNSC	IFI35 →	+1.225	+0.333	<.001	<.001	3	7
UCEC	ETV7 →	+0.899	+0.249	.002	.003	3	6
OV	PSME2 →	+0.766	+0.445	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,969 associations by consensus.

GSDMD vs UBE2L6 — COAD

Explore this scatter interactively →