GSDMD

Across TCGA cell cohorts, GSDMD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,585 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GSDMD-associated GO terms across cancer lineages are Pyroptotic cell death, Actomyosin contractile ring assembly actin filament organization, and Regulation of cytokine-mediated signaling pathway. Each is linked with GSDMD in more than 13 cancer types. Because this analysis shows association rather than direction, both GSDMD-to-partner and partner-to-GSDMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyroptotic cell death grouped by GSDMD-low versus GSDMD-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMD→partner) and Y-score (partner→GSDMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Pyroptotic cell death →	+0.921	+1.771	<.001	.001	3	14
CNS	Actomyosin contractile ring assembly actin filament organization →	+0.192	+2.049	<.001	<.001	3	11
SOFT_TISSUE	Regulation of cytokine-mediated signaling pathway →	+0.064	+3.043	.002	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular transport →	+0.064	+1.741	.002	.005	3	10
LUNG_NSCLC_LUAD	Protein auto-ADP-ribosylation →	+0.108	+1.955	<.001	<.001	3	10
BONE	Pyroptotic inflammatory response →	+0.144	+2.976	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,585 associations by consensus.

Pyroptotic cell death by GSDMD expression — LUNG_SCLC

Explore this box plot interactively →