GSDMD

Across TCGA cell cohorts, GSDMD mutation is significantly associated with the mutation status of many other genes, with 3,423 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSDMD-associated genes across cancer lineages are PYGB, DEF8, and TTC22. Each is linked with GSDMD in more than 3 cancer types. Because this analysis shows association rather than direction, both GSDMD-to-partner and partner-to-GSDMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYGB grouped by GSDMD-low versus GSDMD-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSDMD→partner) and Y-score (partner→GSDMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PYGB →	+3.087	+4.000	.008	.008	1	4
OVARY	DEF8 →	+4.977	+4.415	.007	.007	1	4
OVARY	TTC22 →	+4.977	+4.415	.007	.007	1	4
BLOOD_Leukemia	ITIH5 →	+3.238	+4.960	<.001	<.001	1	4
BLOOD_Leukemia	AGRN →	+2.560	+4.364	.002	.002	1	4
OVARY	TCF20 →	+3.240	+4.467	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,423 associations by consensus.

PYGB by GSDMD expression — URINARY_TRACT

Explore this box plot interactively →