GSC2

Across TCGA patient cohorts, GSC2 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSC2-associated genes across cancer lineages are RN7SL640P, RN7SL237P, and MIR4510. Each is linked with GSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSC2-to-partner and partner-to-GSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL640P grouped by GSC2-low versus GSC2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSC2→partner) and Y-score (partner→GSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL640P →	+0.119	+7.924	<.001	.008	3	1
UCEC	RN7SL237P →	+0.349	+4.496	.008	.002	3	1
UCEC	MIR4510 →	+0.387	+4.868	<.001	.004	3	1
UCEC	MIR4764 →	+0.529	+4.641	<.001	.006	3	1
UCEC	ATP6V1E1P2 →	+0.227	+3.661	.008	.009	3	1
UCEC	ATP5MGP6 →	+0.417	+4.003	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

RN7SL640P by GSC2 expression — LUSC

Explore this box plot interactively →