GSC2

Across TCGA pan-cancer cohorts, GSC2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated GSC2 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher GSC2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSC2 expression acts as an unfavorable survival marker, although some lineages such as LGG and GBM show a favorable association.

MESO, ACC, and DLBC are the cancer types where GSC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.184	0.387	.001	117	view →
ACC	OS	Tertile	All	0.132	0.727	<.001	81	view →
DLBC	OS	Tertile	III,IV	0.172	0.907	<.001	54	view →
LGG	OS	Median	All	0.881	0.735	<.001	37	view →
SKCM	OS	Tertile	All	0.685	0.817	.001	33	view →
KICH	OS	Tertile	All	0.601	0.955	.014	30	view →
GBM	DFS	Tertile	All	0.327	0.208	.015	21	view →
THYM	OS	Tertile	II,III,IV	0.304	0.882	<.001	21	view →
ESCA	OS	Tertile	All	1.000	0.617	.035	21	view →
LIHC	DFS	Tertile	III,IV	0.116	0.350	.005	18	view →
LUSC	DFS	Tertile	II,III,IV	0.815	0.666	.011	14	view →
UVM	DFS	Tertile	All	0.318	0.605	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GSC2–MESO (DFS)

Open the MESO breakdown →