GSC2

Across TCGA cell cohorts, GSC2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSC2-associated genes across cancer lineages are OR4K2 and MINDY4B. Each is linked with GSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSC2-to-partner and partner-to-GSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K2 grouped by GSC2-low versus GSC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSC2→partner) and Y-score (partner→GSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1
BLOOD_Leukemia	MINDY4B →	+0.486	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR4K2 by GSC2 expression — BLOOD_Leukemia

Explore this box plot interactively →