GSC

Across TCGA patient cohorts, GSC mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSC-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and Gab2. Each is linked with GSC in more than 1 cancer types. Because this analysis shows association rather than direction, both GSC-to-partner and partner-to-GSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GSC-low versus GSC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSC→partner) and Y-score (partner→GSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.127	-3.149	.008	.019	3	1
UCEC	EGFR_pY1068 →	-0.314	-2.999	.009	.035	3	1
UCEC	Gab2 →	+0.527	+2.459	.002	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.446	.017	.020	3	1
UCEC	JNK2 →	+0.279	+3.009	.003	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.209	+2.472	.036	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by GSC expression — UCEC

Explore this box plot interactively →