GSC

Across TCGA cell cohorts, GSC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,174 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GSC-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with GSC in more than 8 cancer types. Because this analysis shows association rather than direction, both GSC-to-partner and partner-to-GSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by GSC-low versus GSC-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSC→partner) and Y-score (partner→GSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RNA splicing, via transesterification reactions →	+0.074	+1.032	.005	.003	3	9
OESOPHAGUS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.073	+1.032	.004	.003	3	9
OESOPHAGUS	mRNA splicing, via spliceosome →	+0.073	+1.032	.004	.003	3	9
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.053	+0.643	<.001	<.001	3	9
OESOPHAGUS	Regulation of myoblast fusion →	+0.133	+1.073	.001	.003	3	8
BREAST	Cell fate commitment →	-0.072	-0.649	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,174 associations by consensus.

RNA splicing, via transesterification reactions by GSC expression — OESOPHAGUS

Explore this box plot interactively →