Across TCGA patient cohorts, GSAP mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSAP-associated genes across cancer lineages are eEF2, MSH2, and MSH6. Each is linked with GSAP in more than 1 cancer types. Because this analysis shows association rather than direction, both GSAP-to-partner and partner-to-GSAP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSAP→partner) and Y-score (partner→GSAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.414	+2.999	.002	.035	3	2
UCEC	MSH2 →	-0.301	-2.674	<.001	.005	3	2
UCEC	MSH6 →	-0.368	-2.169	.002	.003	3	2
UCEC	N-Ras →	-0.123	-1.680	.005	.042	3	2
UCEC	Akt_pT308 →	+0.549	+1.700	.020	.042	3	2
COAD	Caspase-7-cleavedD198 →	+0.962	+3.008	.019	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

GSAP survival (RNA) · tumor vs normal (RNA) · all GSAP data types