GRWD1

Across TCGA patient cohorts, GRWD1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRWD1-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and ERK2. Each is linked with GRWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRWD1-to-partner and partner-to-GRWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by GRWD1-low versus GRWD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRWD1→partner) and Y-score (partner→GRWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.113	+3.169	.005	.020	3	2
UCEC	EGFR_pY1068 →	-0.287	-3.169	.037	.020	3	1
UCEC	ERK2 →	+0.291	+3.169	.005	.020	3	1
UCEC	MEK1_p_S217_S221 →	-0.380	-3.000	.011	.036	3	1
UCEC	PCNA →	+0.411	+3.169	<.001	.020	3	1
UCEC	Bak →	+0.386	+3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

c-Met_pY1235 by GRWD1 expression — UCEC

Explore this box plot interactively →