GRPR

Across TCGA patient cohorts, GRPR mutation is significantly associated with the RNA expression of many other genes, with 2,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRPR-associated genes across cancer lineages are NIPA2P5, RPP21, and RNA5SP452. Each is linked with GRPR in more than 2 cancer types. Because this analysis shows association rather than direction, both GRPR-to-partner and partner-to-GRPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPA2P5 grouped by GRPR-low versus GRPR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRPR→partner) and Y-score (partner→GRPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NIPA2P5 →	+0.026	+3.199	<.001	.005	3	3
SKCM	RPP21 →	+0.495	+3.826	.002	<.001	3	3
CESC	RNA5SP452 →	+0.326	+4.234	.003	.003	3	2
CESC	TRIM64EP →	+0.042	+4.384	<.001	.008	3	2
LUSC	RN7SKP3 →	+0.120	+4.578	<.001	.005	3	2
LUSC	RNU2-60P →	+0.379	+3.602	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,149 associations by consensus.

NIPA2P5 by GRPR expression — SKCM

Explore this box plot interactively →