GRP

Across TCGA pan-cancer cohorts, GRP mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of GRP’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where GRP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GRP is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where GRP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	III,IV	−2.211	<.001	9	view →
LSCC	Male	II,III,IV	−1.719	<.001	8	view →
LUAD	Female	II,III,IV	−1.743	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

GRP–PDAC

Open the PDAC breakdown →