GRP

Across TCGA pan-cancer cohorts, GRP RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GRP data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher GRP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GRP expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

STAD, KIRP, and COAD are the cancer types where GRP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.542	0.704	.003	79	view →
KIRP	OS	Quartile	III,IV	0.114	0.549	.001	73	view →
COAD	OS	Tertile	All	0.401	0.670	.011	22	view →
LIHC	DFS	Quartile	All	0.315	0.472	<.001	17	view →
GBM	OS	Tertile	All	0.338	0.501	.005	16	view →
SCLC	OS	Median	All	0.407	1.000	<.001	10	view →
BLCA	DFS	Median	II,III,IV	0.268	0.402	.011	10	view →
DLBC	DFS	Tertile	IV	0.120	0.827	.025	9	view →
LGG	OS	Median	All	0.927	0.864	.006	6	view →
ESCA	OS	Median	All	1.000	0.449	.011	6	view →
TGCT	DFS	Quartile	All	0.474	0.763	.049	4	view →
KICH	DFS	Quartile	III,IV	0.289	0.885	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GRP–STAD (OS)

Open the STAD breakdown →