GRP

Across TCGA patient cohorts, GRP mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRP-associated genes across cancer lineages are NUTF2P8, RN7SKP36, and MIR5696. Each is linked with GRP in more than 1 cancer types. Because this analysis shows association rather than direction, both GRP-to-partner and partner-to-GRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTF2P8 grouped by GRP-low versus GRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRP→partner) and Y-score (partner→GRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUTF2P8 →	+0.247	+3.982	<.001	<.001	3	2
SARC	RN7SKP36 →	+0.149	+5.620	<.001	.004	3	2
SKCM	MIR5696 →	+0.739	+5.037	<.001	.009	3	2
UCEC	RPL23AP90 →	+0.386	+3.004	.009	.006	3	1
UCEC	MIR6133 →	+0.536	+3.246	<.001	.008	3	1
SARC	RPS15AP34 →	+0.115	+5.111	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

NUTF2P8 by GRP expression — UCEC

Explore this box plot interactively →