GRP

Across TCGA cell cohorts, GRP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,573 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GRP-associated GO terms across cancer lineages are Negative regulation of transmission of nerve impulse, Negative regulation of calcium ion transport into cytosol, and Regulation of microtubule-based process. Each is linked with GRP in more than 9 cancer types. Because this analysis shows association rather than direction, both GRP-to-partner and partner-to-GRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transmission of nerve impulse grouped by GRP-low versus GRP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRP→partner) and Y-score (partner→GRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of transmission of nerve impulse →	+2.989	+6.927	<.001	<.001	3	10
BONE	Negative regulation of calcium ion transport into cytosol →	-0.172	-4.485	.004	.003	3	7
LARGE_INTESTINE	Regulation of microtubule-based process →	+0.024	+0.113	.002	.009	3	7
LUNG_SCLC	Regulation of myoblast fusion →	+0.069	+3.301	.003	.006	3	7
BLOOD_Lymphoma	Psychomotor behavior →	-0.132	-0.153	.001	.004	3	7
BONE	Nuclear DNA replication →	+0.132	+4.270	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,573 associations by consensus.

Negative regulation of transmission of nerve impulse by GRP expression — BONE

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