GRN

Across TCGA patient cohorts, GRN mutation is significantly associated with the RNA expression of many other genes, with 1,285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRN-associated genes across cancer lineages are MTHFD2P3, MIR6851, and ERI1. Each is linked with GRN in more than 2 cancer types. Because this analysis shows association rather than direction, both GRN-to-partner and partner-to-GRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2P3 grouped by GRN-low versus GRN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRN→partner) and Y-score (partner→GRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTHFD2P3 →	+0.153	+3.328	<.001	<.001	3	3
UCEC	MIR6851 →	+0.412	+1.709	<.001	.009	3	3
UCEC	ERI1 →	+0.583	+2.179	.001	.009	3	3
UCEC	ESCO2 →	+0.615	+2.815	.002	.001	3	3
UCEC	RPL23AP53 →	+0.531	+2.931	<.001	<.001	3	3
UCEC	MIR3153 →	+0.813	+1.849	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,285 associations by consensus.

MTHFD2P3 by GRN expression — SKCM

Explore this box plot interactively →